In vivo study | During the LMA task, rat core body temperature are modestly decreased.Oxytocin acetate (subcutaneousinjection; 0.1 mg/kg-0.3 mg/kg; single dose) produces significantly greater hypothermia (at 0.3 mg/kg) than either saline or the two lower doses of oxytocin. Oxytocin at 0.3 mg/kg produces a significantly greater decrease in temperature than vehicle between 15-60 min post injection, whereas 0.1 mg/kg slightly decreases temperature at the 30 min time point only.Oxytocin acetate (0.1 mg/kg) engages in significantly more body sniffing and ano-genital sniffing compared with saline controls. It also increases the total time spent in social interaction (71.6±4.3 s), compared to those receiving vehicle (56.9±4.1 s). Animal Model: Fifty-six male Lister-hooded rats (150–200 g) Dosage: 0.1 mg/kg-0.3 mg/kg Administration: Subcutaneousinjection; 0.1 mg/kg-0.3 mg/kg; single dose Result: Produced significantly greater hypothermia (at 0.3 mg/kg) than the saline group. |